LUTALYSE Injection

Lutalyse® Injection is used for controlling the timing of estrus in estrous cycling mares. Also for difficult to breed mares (clinically anestrous mares that have a corpus luteum). A synchronized breeding program with Lutalyse® for horses can aid in: synchronizing estrus in broodmares, shortening the diestrus interval, grouping estrus mares for AI breeding programs, scheduling the use of stallions in natural breeding programs and managing mares with extended diestrus intervals.

Disposal of Unused Prescription Medications Return unwanted or unused medications to Revival Animal Health in person, or visit www.disposemymeds.org to find a pharmacy near you. A secondary method of drug disposal is to remove the unwanted medication from any wrappers or containers and place it in a plastic bag with moist coffee grounds or cat litter. This can be disposed of in the regular garbage collection. Please do NOT dispose of unwanted meds down the drain or toilet, as this may eventually find its way into the human water supply. Learn more about disposal of unused prescription medications here. Disposal of Medical Sharps When you're finished with the syringe and needle, do not try to recap, remove, bend or break the needle. This is where most injuries occur. Dispose the syringe and needle immediately in a nearby sharps container. All sharps must be deposited in a puncture-proof container. Make sure your storage location is child and animal proof. As with all product handling, make sure you wash your hands after handling medical sharps. Disposal of Sharps Container When your sharps container is half-full, sift dry Portland Cement throughout the sharps. Fill the container with water, and rotate until the cement is mixed and the sharps have been distributed throughout the cement mixture. Let cement dry for 24 hours. Seal the lid of the container tightly and use duct tape to seal. Label the container "Livestock Sharps" to properly identify the contents. Dispose of the containers in accordance with your state's regulations.

Side Effects: Mares: The most frequently observed side effects are sweating and decreased rectal temperature. However, these have been transient in all cases observed and have not been detrimental to the animal. Other reactions seen have been increase in heart rate, increase in respiration rate, some abdominal discomfort, locomotor incoordination, and lying down. These effects are usually seen within 15 minutes of injection and disappear within one hour. Mares usually continue to eat during the period of expression of side effects. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. Warnings: No vial stopper should be entered more than 20 times. For this reason, the 100 mL bottle should only be used for cattle. The 30 mL bottle may be used for cattle, swine, or mares.User Safety: Not for use in humans. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water. Residue Warnings: Use of this product in excess of the approved dose may result in drug residues. Do not use in horses intended for human consumption. Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE® Injection have been reported. In rare instances, such infections have resulted in death. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. Do not administer intravenously (IV) as this route may potentiate adverse reactions. Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. In mares, LUTALYSE Injection is ineffective when administered prior to day-5 after ovulation. Mare pregnancy status should be determined prior to treatment since LUTALYSE Injection has been reported to induce abortion and parturition when sufficient doses were administered. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract.Overdoses can be very dangerous. Keep out of reach of children and animals. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.This medication should only be given to the pet for whom it was prescribed.

Active Ingredients: LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. Storage: Store at controlled room temperature 20° to 25°C (68° to 77°F). Use contents within 12 weeks of first vial puncture. Protect from freezing.

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